Epigenetic Mechanisms in Heart Failure Pathogenesis
نویسندگان
چکیده
منابع مشابه
Epigenetic mechanisms in heart failure pathogenesis.
A lthough neurohormonal antagonist and device therapies have improved outcomes in patients with systolic heart failure (HF), residual morbidity and mortality remain high. Novel HF therapeutic approaches thus remain an unmet clinical need of pressing urgency. Such approaches depend, in turn, on keener understanding of the molecular pathways underlying HF pathogenesis. Although a number of novel ...
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Pharmacopuncture treatments are proposed for cardiovascular disease and heart failure [1]. Heart failure results from complex environment-gene interactions. β-adrenergic receptors and protein kinase A (PKA) interact with histones and related segments of deoxyribonucleic acid (DNA) at promoter regions of genes for messenger ribo nucleic acid (mRNA) transcription. This increases cardiac muscle ma...
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Transcriptional dysregulation is an early event and may be an important pathological mechanism in Huntington's disease (HD). However, the exact process that leads to alterations in gene expression in HD is not clear. One potential mechanism underlying transcriptional abnormalities in HD may be epigenetic alterations which regulate gene expression without changing the DNA sequence. Previous work...
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Tissue inhibitor of matrix metalloprotease 4 (TIMP4) is endogenously one of the key modulators of matrix metalloprotease 9 (MMP9) and we have reported earlier that cardiac specific TIMP4 instigates contractility and helps in differentiation of cardiac progenitor cells. Although studies show that the expression of TIMP4 goes down in heart failure but the mechanism is unknown. This study aims to ...
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ژورنال
عنوان ژورنال: Circulation: Heart Failure
سال: 2014
ISSN: 1941-3289,1941-3297
DOI: 10.1161/circheartfailure.114.001193